PT - JOURNAL ARTICLE AU - Spevak, Aimee ED - Sabatine, Marc S. TI - Evolocumab Effectively Lowers LDL-C, Decreases Cardiovascular Outcomes in OSLER DP - 2015 May 24 TA - MD Conference Express PG - 10--11 VI - 15 IP - 5 4099 - http://mdc.sagepub.com/content/15/5/10.short 4100 - http://mdc.sagepub.com/content/15/5/10.full AB - The OSLER extension studies randomized patients to receive standard of care or standard of care plus evolocumab. At 1 year, evolocumab lowered low-density lipoprotein cholesterol by 61% and demonstrated preliminary evidence that this may reduce the risk of cardiovascular events. Evolocumab was well tolerated across all gradients of achieved low-density lipoprotein cholesterol levels.