PT - JOURNAL ARTICLE AU - Lederman, Lynne ED - Swanton, Charles TI - Better Molecular Profiling is Needed for Rational, Targeted Therapy in CRC DP - 2014 Aug 01 TA - MD Conference Express PG - 22--23 VI - 14 IP - 14 4099 - http://mdc.sagepub.com/content/14/14/22.short 4100 - http://mdc.sagepub.com/content/14/14/22.full AB - Colorectal cancer (CRC) was one the first solid malignancies to be classified using molecular profiling, and led to the identification of critical genes and pathways involved in this disease. This article discusses future directions of biomarker research, the molecular biomarker characterization and subtyping of CRC, and the implications of tumor heterogeneity.