RT Journal Article SR Electronic A1 Spevak, Aimee T1 Evolocumab Effectively Lowers LDL-C, Decreases Cardiovascular Outcomes in OSLER JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 5 SP 10 OP 11 DO 10.1177/1559897715583660 UL http://mdc.sagepub.com/content/15/5/10.abstract AB The OSLER extension studies randomized patients to receive standard of care or standard of care plus evolocumab. At 1 year, evolocumab lowered low-density lipoprotein cholesterol by 61% and demonstrated preliminary evidence that this may reduce the risk of cardiovascular events. Evolocumab was well tolerated across all gradients of achieved low-density lipoprotein cholesterol levels.